creb protein การใช้

• CREB proteins are expressed in many animals, including humans.
• It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein.
• CREB proteins are activated by phosphorylation from various kinases, including leucine zipper motif.
• For example, the LTP, and this is accompanied by a reduction in the transcription of genes modulated by the CREB protein.
• Use of the LBD system to knock down CREB protein function during training ( using both contextual freezing and tone fear paradigms ) produced a deficit in long-term, but not short-term, memory.
• Glucagon indirectly elevates the expression of PEPCK-C by increasing the levels of cAMP ( via activation of adenylyl cyclase ) in the liver which consequently leads to the phosphorylation of S133 on a beta sheet in the CREB protein.
• Some CREB-target genes, relevant for understanding alcoholism, include NPY, BDNF, Arc, and CRF . Levels of CREB and p-CREB ( a highly phosphorylated CREB protein ) play a dynamic role in the preference for, consumption of, and dependence on ethanol.